I was at home doing some chores when all of a sudden I started to compare and contrast House and Holmes. They're both drug addicts(House vycodin Holmes morphine.), they both have people to help with their jobs (Baker Street Irregulars Houses Group), both have close friends(Wilson and Watson.) , and both are pompous and arrogant (House more so). The one difference is Holmes has the ability to deduce House doesn't. Can anyone compare and contrast these fictional characters?

Wikipedia reference to House/Holmes

References to Sherlock Holmes
Sherlock Holmes serves as an inspiration for the series.

Similarities between Gregory House and the famous fictional detective Sherlock Holmes, created by Arthur Conan Doyle, appear throughout the series. Shore explained that he was always a Holmes fan, and found the character's indifference to his clients unique. The resemblance is evident in House's reliance on psychology in problem-solving, even where it might not seem obviously applicable, and his reluctance to accept cases he finds uninteresting. In almost every episode, his investigatory method is to logically eliminate diagnoses as they are proved impossible; Holmes uses a similar method. Both characters play instruments (House plays the piano, the guitar, and the harmonica; Holmes, the violin) and take drugs (House is addicted to Vicodin; Holmes uses cocaine recreationally). House's relationship with Dr. James Wilson echoes that between Holmes and his confidant, Dr. John Watson. Robert Sean Leonard, who portrays Wilson, said that House and his character—whose name is very similar to Watson's—were originally intended to work together much as Holmes and Watson do; in his view, House's team has assumed that aspect of the Watson role. Shore said that House's name itself is meant as "a subtle homage" to Holmes. The number of House's apartment, 221B, is a reference to Holmes's street address.

Individual episodes of the series contain additional references to the Sherlock Holmes tales. The main patient in the pilot episode is named Rebecca Adler, after Irene Adler, a character in the first Holmes short story. In the season 2 finale, House is shot by a crazed gunman credited as "Moriarty", the name of Holmes's nemesis. In the season 4 episode "It's a Wonderful Lie", House receives a "second edition Conan Doyle" as a Christmas gift. In the season 5 episode "Joy to the World", Wilson gives House a book by Joseph Bell, Conan Doyle's inspiration for Sherlock Holmes, as a Christmas present. Wilson includes a message that reads, "Greg, It made me think of you", and names an Irene Adler as the alleged sender before taking credit.

I see that House and Holmes are the same but still different in many ways, as while House is a doctor, Holmes started out as wanting to be a doctor, but slowly became a detective, though the skills he got as a doctor helped him in detecting, he still did not stay as a doctor. And, when a doctor Holmes worked under someone, while House is the director of a whole department. Though personality wise they are similar, in their fields, they are completely different.