At the end of the second episode, it made it pretty clear that Sam was possibly involved in why Lou's missing. It seems like we're being lead to wonder if Sam's the one stealing from people (the hand taking money in drawers) and also if he's part of the reason Lou's missing.
I think Lou's missing more to make Kenny and Sam suspects so the romances with everyone have to slow down for Molly. She can't get in a relationship yet, that'd be too boring! So now it has to look scandalous that Kenny might've been involved because of business issues and that Lou was supposed to have dinner with his wife. And of course Sam is suspected because his blood was on Lou's porch... and because we're not supposed to just think he's a hot, kind homeless guy wandering around.
So I don't know if this means Lou dies, but I hope not because he's a good character. Hopefully it's just for some drama then he'll be back!!
http://getreel.sidereel.com/2007/06/14/sta...ie-on-the-loose
